Guyana is scheduled to compete at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023. This will be Guyana's 17th appearance at the Pan American Games, having competed at every edition of the games since the third edition in 1959.
On October 14, a final team of 19 athletes competing in eight sports was announced by the Guyana Olympic Association. Boxer Desmond Amsterdam and badminton athlete Priyanna Ramdhani were the country's flagbearers during the opening ceremony. Meanwhile, javelin thrower Leslain Baird was the country's flagbearer during the closing ceremony.
The following is the list of the number of competitors (per gender) participating at the games per sport/discipline.
The following Guyanese competitors won medals at the games. In the discipline sections below, the medalists' names are bolded.
Guyana qualified one archer during the 2023 Copa Merengue. This will mark the country's Pan American Games debut in the sport.
Guyana qualified five track and field athletes (two men and three women).
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Guyana qualified one female athlete.
Guyana qualified two male boxers, both of whom qualified through the final Pan American Games qualifier held in Cali, Colombia. The boxing event was an open entry event, which allowed Guyana to enter a further two male and one female boxers.
Guyana qualified two swimmers (one per gender).
Guyana qualified one male table tennis athlete at the final qualification tournament in Lima, Peru. Guyana would be later awarded a wildcard in the women's singles event, bringing the team size up to two athletes (one per gender).
Guyana qualified one female athlete during the Pan American Games Qualification Tournament.
Kyorugi
Guyana was awarded a wildcard to send one male weightlifter. Guyana later received an additional quota for a women's weightlifter, meaning the team size was two athletes (one man and one woman).
Guyana qualified one female athlete. This athlete is not included in the total, because esports is a demonstration sport.