Guyana competed in the 2015 Pan American Games in Toronto, Ontario, Canada from July 10 to 26, 2015.
Guyana's team consisted of 22 athletes (19 men and three women) competing in five sports. Swimmer Onika George was the flagbearer for the team during the opening ceremony.
The following table lists Guyana's delegation per sport and gender.
Guyana's track and field team consisted of three athletes (two men and one woman).
Guyana received two quota spots to enter one male and one female.
Guyana qualified a men's rugby sevens team, after winning the 2014 NACRA Sevens held in December 2014. The team consisted of twelve athletes.
Guyana qualified a men's squash team of three athletes.
Guyana received two universality spots (one male and one female).