Guthrie Branch is a long 1st order tributary to C and D Canal in New Castle County, Delaware.
According to the Geographic Names Information System, it has also been known historically as:
Guthrie Branch rises on the Long Creek divide about 0.2 miles east of Pencader Farms in New Castle County, Delaware. Guthrie Branch then flows south to meet the C and D Canal about 1.5 miles east of Chesapeake City, Maryland.
Guthrie Branch drains of area, receives about 44.9 in/year of precipitation, has a topographic wetness index of 652.80 and is about 26.2% forested.