Gustavo Adrián Semino (born July 7, 1977) is a former Argentine footballer who played as a defender.
Following his retirement, Semino moved to Paraguay and played friendly matches with Club Athletic FBC from Encarnación, at the same time he performed as coach of the youth teams. Semino has also worked for a football academy as coach and scout. Strongly related to Atlético Rafaela, he assumed as coach for youth teams in 2024.