The Guise baronetcy, of Highnam Court in the County of Gloucester, was created in the Baronetage of Great Britain on 9 December 1783 for John Guise, the cousin and heir male of the 5th and last Baronet of the 1661 creation who had died that year. He was the great-grandson of Henry Guise, younger brother of the 1st Baronet.
The 2nd Baronet sat as MP for Gloucestershire and Gloucestershire East. The 3rd Baronet, his brother General Sir John Wright Guise, 3rd Baronet, commanded a Guards battalion in the Peninsular War.
The 4th, 5th, and 6th Baronets all served as High Sheriff of Gloucestershire.
In 1863 the 3rd Baronet was granted heraldic supporters, usually only borne by peers, to descend to heirs male on succession to the baronetcy. The motto is Quo honestior eo tutior, The more honest, the more safe.