Guido Cominotto (Mestre, 4 October 1901 - 9 March 1967) was an Italian sprinter (400 m) and middle distance runner (800 m).
Guido Cominotto participated at two editions of the Summer Olympics (1924, 1928), he had 7 caps in national team from 1924 to 1928.
Guido Cominotto has won 6 times the individual national championship.