Gui ( or ), or Kwai () in Cantonese, is a Chinese surname. Notable people with this surname include:
- Gui Minhai ( or ; born 1964), Chinese-born Swedish book publisher and writer
- Gwei Lun-mei (; born 1983), Taiwanese actress
- Gui Hong (; born 1995), Chinese footballer
- Gua Ah-leh (; born 1944), Taiwanese actress and singer
- Gui Haichao (), Chinese astronaut
- Nancy Kwai (; born 2000), Hong Kong singer and actress