Grondona (Grondonn-a in Ligurian) is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about southeast of Turin and about southeast of Alessandria. As of 31 December 2004, it had a population of 548 and an area of .
The municipality of Grondona contains the frazione (subdivision) Variana.
Grondona borders the following municipalities: Arquata Scrivia, Borghetto di Borbera, Isola del Cantone, Roccaforte Ligure, and Vignole Borbera.