The twenty-second season of the American medical drama television series Grey's Anatomy was announced on April 3, 2025, and premiered in the United States on the American Broadcasting Company (ABC) on October 9, 2025.
This is the first season not to feature Jake Borelli and Midori Francis as series regulars since the sixteenth and nineteenth seasons, respectively.
On March 25, 2026, it was announced that series regulars Kevin McKidd (Dr. Owen Hunt) and Kim Raver (Dr. Teddy Altman) will depart the series after the season finale.
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On April 3, 2025, ABC renewed the series for a twenty-second season with Meg Marinis' third year as showrunner. The season consists of 18 episodes, consistent with the episode order of Season 21. It surpassed the 450 episode mark during episode 2, extending its record as the longest-running American primetime medical drama. Filming began on August 1. Season 22 premiered in the United States on October 9, 2025.
Ellen Pompeo will continue to narrate the series and receive star billing, appearing in seven episodes, as she did in Season 21. Chandra Wilson and James Pickens Jr. remain the only original cast members confirmed to appear in all 18 episodes. On October 9, 2025, Trevor Jackson, who guest starred as Dr. Wes Bryant in the last two episodes of Season 21, was promoted to a series regular.
Continuing from last season, the minimum episode guarantee for most series regulars was reduced to 14 out of 18 episodes. However, longtime cast member Caterina Scorsone's role was further scaled back, resulting in a total of 11 appearances for the season. Following her character's sabbatical in episode two, Scorsone was absent for seven episodes, returning for episode 10 in January 2026.
In November 2025, James Pickens Jr. opened up about his prostate cancer diagnosis, which now mirrors the storyline of his character Dr. Richard Webber, who revealed he has cancer in the mid-season finale. Subsequently, he announced being cancer-free.
In December 2025, it was revealed that Kate Walsh will reprise her role as Dr. Addison Montgomery in episode 10, titled "Strip That Down", airing January 29, 2026.
In January 2026, actress Jamie-Lynn Sigler would guest star as Dr. Laura Kaplan, a doctor suffering from multiple sclerosis (MS), in episode which "Heavy on Me," which aired on January 15, 2026. The guest appearance was a nod to Sigler's real life MS condition and was also deemed a way of showing her real life condition openly to a television audience.
On March 25, 2026, it was announced that series regulars Kevin McKidd (Dr. Owen Hunt) and Kim Raver (Dr. Teddy Altman) will depart the series after the season finale.
In February 2026, Grey's Anatomy was reported to likely receive a 23rd season renewal from ABC. The potential renewal was said to involve additional budget reductions, which could affect the episode order and cast. In recent seasons, veteran cast members had already seen their episode guarantees reduced as part of cost-cutting measures, and further cast departures were described as possible. On March 30, 2026, ABC officially renewed the series for a twenty-third season with Meg Marinis' fourth year as showrunner.