Greek National Road 53 (), abbreviated as the EO53, is a national road in northeastern Greece. The EO53 runs within the Evros regional unit, from Alexandroupolis to Mikro Dereio near the border with Bulgaria: however, the border crossing itself is unbuilt.
The EO53 is officially defined as a northâÂÂsouth road within the Evros regional unit: the EO55 runs between Alexandroupolis and Mikro Dereio, via Aisymi and Mega Dereio: however, the border crossing itself, over the Erythropotamos, is unbuilt. The EO53 connects with the EO2 in Alexandroupolis.
Ministerial Decision G25871 of 9 July 1963 created the EO53 from the old EO49, which existed by royal decree from 1955 until 1963, and followed the same route as the current EO53.