Greek National Road 16 (, abbreviated as EO16) is a single carriageway road (throughout most of its length) in northern Greece. It connects Thessaloniki with Ierissos in Chalkidiki. At its beginning in Thessaloniki, it forms the Georgikis Scholis Highway, with three lanes in each direction, passing through one of the city's main commercial districts.
The road passes through the following places:
Ministerial Decision G25871 of 9 July 1963 created the EO16 from the main route of the old EO40, which existed by royal decree from 1955 until 1963, and followed the same route as the current EO16: the Thessaloniki Airport branch of the old EO40 was given to the EO67, while the Polygyros branch was given to the EO16a.