The Great Mosque of Ramla () is a mosque in Ramla, in the Central District of Israel.
The mosque was constructed in 12th century as a church. In 1266 CE, during the Mamluk Sultanate rule, the church was transformed into a mosque. A mihrab and minaret were added to the structure.
The mosque consists of three parallel halls, a nave and two transepts.
The mosque is accessible within walking distance south of Ramla Station of Israel Railways.