Greasy Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of McKenzie Creek.
The stream headwaters arise at and the stream flows generally south to its confluence with McKenzie Creek at at an elevation of . The stream mouth is about two miles north of Piedmont. An area in the upper reaches of the stream is impounded as Dover Lake.
Greasy Creek most likely was so named on account of the often muddy character of its water.