Greasy Creek is a stream in Madison County in the U.S. state of Missouri. It is a tributary of the Castor River.
The stream headwaters arise at southwest of Missouri Route A. the stream floes to the southeast parallel to Route A and passes the community of Klendike. It gradually turns to the east and passes under Route A to its confluence with the Castor River just to the north of Marquand at .
Greasy Creek was named for the greasewood timber near its course, according to local history.