Grande-Rivière-du-Nord (; ) is a commune in the Grande-Rivière-du-Nord Arrondissement, in the Nord Department of Haiti. Jean-Jacques Dessalines was born there in 1758 on the Cormiers plantation.
The town was established in 1712, and named after a nearby river. In addition to being the birthplace of Dessalines, it is the hometown of Jean Price-Mars, Jean-Baptiste Chavannes, Henry Namphy, Vilbrun Guillaume Sam, Tirésias Simon Sam, Jean-Baptiste Riché, and Philippe Guerrier. Grande-Rivière has retained a significant amount of colonial-era architecture.
Local landmarks include the Church of St. Rose of Lima, first built in 1712, and the Dessalines monument, unveiled in 2022. The town is a national hub of cocoa and coffee production. A team of Canadian students set up a computer-equipped library in the town in 2017.