Graffignano is a (municipality) in the Province of Viterbo in the Italian region of Latium, located about northwest of Rome and about northeast of Viterbo.
Graffignano borders the following municipalities: Alviano, Attigliano, Bomarzo, Civitella d'Agliano, Lugnano in Teverina, Viterbo.
Sights include the Baglioni Castle (13th century), church of San Martino Vescovo.