Goff Creek is a stream in Stone County in the Ozarks of southwest Missouri. It is a tributary of the James River.
The headwaters are the junction of the East Prong Goff Creek and West Prong Goff Creek at and the confluence with the James is at . The East Prong flows past Ponce de Leon and the West Prong flows north from Abesville on Missouri Route 176. The two converge and flow northwest under Missouri Route V and past White City on to join the James just south of the McCall Bridge.
Goff Creek has the name of John Goff, a pioneer settler.