Glycerol-3-phosphate dehydrogenase (NAD+)

In enzymology, a glycerol-3-phosphate dehydrogenase (NAD⁺) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are sn-glycerol 3-phosphate and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are dihydroxyacetone phosphate, the reduced cofactor NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD⁺ 2-oxidoreductase. Other names in common use include alpha-glycerol phosphate dehydrogenase (NAD⁺), alpha-glycerophosphate dehydrogenase (NAD⁺), glycerol 1-phosphate dehydrogenase, glycerol phosphate dehydrogenase (NAD⁺), glycerophosphate dehydrogenase (NAD⁺), hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase, NAD⁺-alpha-glycerophosphate dehydrogenase, NAD⁺-dependent glycerol phosphate dehydrogenase, NAD⁺-dependent glycerol-3-phosphate dehydrogenase, NAD⁺-L-glycerol-3-phosphate dehydrogenase, NAD⁺-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, and glycerol-3-phosphate dehydrogenase (NAD⁺). This enzyme participates in glycerophospholipid metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , and .

See also

• sn-glycerol-1-phosphate dehydrogenase which acts on the enantiomer of sn glycerol 3-phosphate

References

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 85-96.