Giovanni Medici may refer to:
- Don Giovanni de' Medici (1567-1621), Italian military commander and diplomat
- Giovanni de' Medici (cardinal) (1543âÂÂ1562), Cardinal of the Holy Roman Church
- Giovanni delle Bande Nere (Ludovico de' Medici, 1498âÂÂ1526), Italian condottiero
- Giovanni di Bicci de' Medici (c. 1360âÂÂ1429), Italian banker
- Giovanni di Cosimo de' Medici (1421âÂÂ1463), Italian banker
- Giovanni il Popolano (Giovanni de' Medici, 1467âÂÂ1498), Italian nobleman
- Pope Leo X (Giovanni di Lorenzo de' Medici, 1475âÂÂ1521), Head of the Catholic Church from 1513 to 1521
- Pope Pius IV (Giovanni Angelo Medici, 1499âÂÂ1565), Head of the Catholic Church from 1559 to 1565