Gignese is a comune (municipality) in the Province of Verbano-Cusio-Ossola in the Italian region Piedmont, located about northeast of Turin and about south of Verbania. As of 31 December 2022, it had a population of 1065 and an area of .
The municipality of Gignese contains the frazioni (subdivisions, mainly villages and hamlets) Alpino, Nocco, and Vezzo.
Gignese borders the following municipalities: Armeno, Brovello-Carpugnino, Omegna, Stresa.