Giffone (Calabrian: or ) is a comune (municipality) in the Province of Reggio Calabria in the Italian region Calabria, located about southwest of Catanzaro and about northeast of Reggio Calabria. As of 31 December 2004, it had a population of 2,154 and an area of .
Giffone borders the following municipalities: Anoia, Cinquefrondi, Galatro, Mammola, Maropati.