Gianpaolo Spagnulo (born 26 September 1964) is an Italian retired footballer who last played for Taranto 1927 in his home country.
Spagnulo started his senior career with S.S.D. Cittàdi Brindisi. In 1992, he signed for Genoa C.F.C. in the Italian Serie A, where he made twenty-four league appearances and scored zero goals. After that, he played for A.C. Pisa 1909, Delfino Pescara 1936, A.C. Perugia Calcio, Esporte Clube Vitória, S.S.D. Casarano Calcio, and Taranto 1927.