Ghaleb Mutahar al-Qamesh (; born 1948) is a Yemeni politician, military and intelligence official. He served as chief of the Political Security Organization, Yemen's intelligence agency, for more than three decades.
Ghaleb was born in Kharif District, Amran Governorate, in 1948. He studied his basic education and grew up in his village al-Assyah in Kharif of Amran northern Yemen. He joined the Military Academy in Sana'a and graduated in 1968.