Germana Di Natale (born 2 April 1974) is a former professional tennis player from Italy.
A right-handed player, Di Natale started playing tennis at the age of ten and began touring in the early 1990s.
Di Natale was a singles bronze medalist at the 1997 Summer Universiade.
As a professional player, she is most noted for her quarterfinal appearance as a qualifier at the 2000 WTA Madrid Open, where she had a win over the top seed Mary Pierce en route. Starting the tournament with a ranking of 258, she upset the world's sixth-ranked player, Pierce, with a straight-sets second-round win. In the quarterfinals, she had to retire hurt while trailing Iva Majoli by a set due to an injury to her right arm.
During her career, she competed in the qualifying draws of all four Grand Slam tournaments.