George Willoughby may refer to:
- George Willoughby (activist) (1914âÂÂ2010), American Quaker activist
- Sir George Willoughby (MP) (c. 1635âÂÂ1695), English MP for Marlborough, 1685âÂÂ1695
- George Willoughby, 7th Baron Willoughby of Parham (1638âÂÂ1674), English peer
- George Willoughby, 17th Baron Willoughby of Parham (1748/9âÂÂ1779), English peer
- George Willoughby (East India Company officer) (1828âÂÂ1857), British soldier in India
- George Willoughby (theatre entrepreneur) (1869âÂÂ1951), English theatre entrepreneur
- George Willoughby (producer), Norwegian film producer