George Sanderson may refer to:
- George P. Sanderson (1848âÂÂ1892), big game hunter in India
- George Henry Sanderson (1824âÂÂ1893), mayor of San Francisco
- George Sanderson (politician) (1810âÂÂ1886), mayor of Lancaster, Pennsylvania
- George Pringle Sanderson (1850âÂÂ1940), Canadian politician from Alberta
- George G. Sanderson (1840âÂÂ1919), insurance broker, shipowner and political figure in Nova Scotia, Canada
- George K. Sanderson (1844âÂÂ1893), U.S. Army officer
- George Plaisted Sanderson (1836âÂÂ1915), mayor of Lynn, Massachusetts
- George A. Sanderson, secretary of the United States Senate
- George Sanderson, a character in the film Monsters, Inc.
- George Sanderson (rugby union)