George Bruce may refer to:
- George Bruce of Carnock (c. 1550âÂÂ1625), Scottish engineer
- George Bruce (industrialist) (1781âÂÂ1866), American printer, industrialist and inventor
- George Barclay Bruce (1821âÂÂ1908), British civil engineer
- George Barrett Bruce (1816âÂÂ1884), American musician and music author
- George Bruce (footballer) (1879âÂÂ1928), Australian rules footballer
- George A. Bruce (1839âÂÂ1929), Massachusetts politician
- George Bruce (writer) (1898âÂÂ1974), Two Years Before the Mast (film)
- George Bruce (poet) (1909âÂÂ2002), Scottish poet
- George Bruce (bishop) (1942âÂÂ2024), bishop of the Anglican Diocese of Ontario
- George Bruce, 7th Lord Balfour of Burleigh (1883âÂÂ1967), Scottish peer and banker