Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene. Wntless is a receptor for Wnt proteins in Wnt-secreting cells.
Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.
A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.