Fritzsche is a German surname. Like Fritsch, Fritsche and Fritzsch, it is a patronymic derived from Friedrich. Notable people with the surname include:
- Carl Julius Fritzsche (1808âÂÂ1871), German chemist
- Christian Friedrich Fritzsche (1776âÂÂ1850), German Protestant theologian
- Franz Volkmar Fritzsche (1806âÂÂ1887), German classical philologist
- Friedrich Wilhelm Fritzsche (1825âÂÂ1905), German parliamentarian and newspaper editor in the United States
- Gotthard Daniel Fritzsche (1797âÂÂ1863), Australian theologian
- Hans Fritzsche (1900âÂÂ1953), German Nazi official
- Hellmut Fritzsche (1927âÂÂ2018), German-American physicist
- Immo Fritzsche (1918âÂÂ1943), German Luftwaffe officer
- Oliver Fritzsche (born 1970), German politician
- Otto Fridolin Fritzsche (1812âÂÂ1896), German theologian
- Ronald Fritzsche (born 1945), American Icthyologist who described the fishes Cosmocampus heraldi,âÂÂSyngnathus macrobrachium, Syngnathus euchrous, Syngnathus insulae, Solenostomus halimeda, â Syngnathus emeritus, and Micrognathus pygmaeus.
- Walter Fritzsche (1903âÂÂ1956), German footballer
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