Frassineto Po is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about east of Turin and about north of Alessandria. As of 31 December 2004, it had a population of 1,462 and an area of .
Frassineto Po borders the following municipalities: Borgo San Martino, Breme, Candia Lomellina, Casale Monferrato, Ticineto, and Valmacca.