Frank Berghuis (born 2 May 1967) is a Dutch former professional footballer who played as a left winger.
Born in Nunspeet, Berghuis played for AGOVV, Apeldoornse Boys, PSV, FC VVV, Zwolle, Volendam, Galatasaray, Lommel and Cambuur.
Nicknamed Pico, he made one international appearance for the Netherlands national team in 1989.
His son Steven Berghuis is also a professional footballer.