Francesco Serini (died 6 September 1598) was a Roman Catholic prelate who served as Bishop of Bagnoregio (1590âÂÂ1598).
On 16 July 1590, Francesco Serini was appointed during the papacy of Pope Sixtus V as Bishop of Bagnoregio. He served as Bishop of Bagnoregio until his death on 6 September 1598. While bishop, he was the principal co-consecrator of Arnaud d'Ossat, Bishop of Rennes.