Francesco Piccolomini (died 1622) was a Roman Catholic prelate who served as Bishop of Grosseto (1611âÂÂ1622).
On 17 August 1611, Francesco Piccolomini was appointed during the papacy of Pope Paul V as Bishop of Grosseto. On 6 November 1611, he was consecrated bishop by Giovanni Garzia Mellini, Cardinal-Priest of Santi Quattro Coronati, with Alessandro Borghi (bishop), Bishop Emeritus of Sansepolcro, and Antonio Maria Franceschini, Bishop of Amelia, serving as co-consecrators. He served as Bishop of Grosseto until his death in May 1622. While bishop, he was the principal co-consecrator of Gregorio Pomodoro, Bishop of Larino (1616) .