In enzymology, a formate dehydrogenase (NADP+) () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are formate and NADP<sup>+</sup>, whereas its two products are CO<sub>2</sub> and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .