Florence is an unincorporated census-designated place in York Township, Switzerland County, in the U.S. state of Indiana. As of the 2020 census, Florence had a population of 60.
The community was laid out in 1817 under the name New York. A post office was established under this name in 1827, and was renamed to Florence in 1847. The post office is still currently operating.
The climate in this area is characterized by hot, humid summers and generally mild to cool winters. According to the Köppen Climate Classification system, Florence has a humid subtropical climate, abbreviated "Cfa" on climate maps.