In enzymology, a flavanone 4-reductase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are (2S)-flavan-4-ol and NADP<sup>+</sup>, whereas its 3 products are (2S)-flavanone, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is (2S)-flavan-4-ol:NADP<sup>+</sup> 4-oxidoreductase. This enzyme participates in flavonoid biosynthesis.