Ficus mathewsii is a species of plant in the family Moraceae. It is native to tropical South America, including in northern and eastern Brazil, Bolivia, Colombia, Ecuador, the Guianas, Peru, and Venezuela.
The species was first described as Urostigma mathewsii by Friedrich Anton Wilhelm Miquel in 1847. In 1867 Miquel placed the species in genus Ficus as F. mathewsii.