Fermanagh and Tyrone was a parliamentary constituency in Northern Ireland which was represented in the House of Commons of the Parliament of the United Kingdom. It elected two Members of Parliament (MPs) using the bloc vote system.
The Government of Ireland Act 1920 established the Parliament of Northern Ireland, which came into operation in 1921. The representation of Northern Ireland at Westminster was reduced from 30 MPs to 13 MPs, taking effect at the 1922 general election. The two-seat county constituency of Fermanagh and Tyrone comprising County Fermanagh and County Tyrone replaced the constituencies of North Fermanagh, Fermanagh South, North East Tyrone, North West Tyrone and South Tyrone. An eight-seat constituency of Fermanagh and Tyrone was also created for the House of Commons of Northern Ireland.
Under the Representation of the People Act 1948, all two-member constituencies were divided. Fermanagh and Tyrone was succeeded by Fermanagh and South Tyrone, with the remainder becoming part of Mid Ulster.
It was the only constituency in Northern Ireland to regularly elect Nationalist MPs. Nationalist MPs were elected in every general election and by-election held in the constituency, except for the 1924 general election, when no Nationalist stood and two Ulster Unionists defeated two Sinn Féin candidates.