Fatma Sultan (; â October 1580) was an Ottoman princess, daughter of Sultan Selim II (reign 1566âÂÂ1574) of the Ottoman Empire. So she was the granddaughter of Suleiman the Magnificent (reign 1520âÂÂ66) and Hürrem Sultan, half-sister of Sultan Murad III (reign 1574âÂÂ1595) and aunt of Sultan Mehmed III (reign 1595âÂÂ1603).
Fatma was born circa 1559 during Selim's princedom, at Konya where he served as sanjakbey, or provincial governor, at the time. She was her father's youngest daughter. Her mother's identity is uncertain.
It was earlier disputed whether she was the daughter of Nurbanu Sultan but considering that Nurbanu accompanied her son, Murad to his province to which he was appointed by his grandfather, Suleiman the Magnificent in 1558 and Fatma was born in 1559, Peirce had debunked this possibility. That Fatma was born with an unknown concubine is further proved by the provision made by her for her mother for 40 aspers, which was definitely not required by a woman paid 1,100 aspers by the end of Selim II's reign as haseki sultan and 2,000 aspers in her son, Murad III's reign as valide sultan and who had died in 1583, predating Fatma's will.
In 1574, she married Kanijeli Siyavuà  Pasha (died 1602), then Beylerbey (governor-general) of Rumelia, and eventually Grand Vizier (1582âÂÂ1584, 1586âÂÂ1589, 1592âÂÂ1593). Stephan Gerlach, first assistant and clergyman to the ambassador of the Holy Roman Empire at Istanbul from 1573 to 1578, recorded word that the Beylerbey was originally a slave whom Fatma's father Selim bought as a boy for 500 ducats and came to regard as his own son. It was in Sultan Selim's will that this marriage be arranged.
Fatma's dowry amounted to approximately 5000 ducats. The marriage was happy, as indicated by the fact that she pleaded with her brother Murad to spare Siyavuà  Pasha's life when at some point the latter fell out of favour. Siyavuà  Pasha's physician, Moses Benveniste was often at dinner with the couple. She bore her husband four sons and a daughter, but only a son survived beyond the infancy.
Fatma had an elementary school, or mektep, as well as a religious college, or medrese, constructed at Edirnekapñ.
Fatma Sultan died in October 1580, at Istanbul, in childbirth as a result of her daughter being born prematurely. The latter reportedly died too. She was entombed in her father Sultan Selim II's mausoleum in Hagia Sophia Mosque. She had a provision made, supported by vakfs, that is, charitable foundations, so that the Quran would be read every morning, for the sake of her soul.
By her marriage, Fatma had four sons and a daughter. Only a son survived after infancy.