Fatehpur Sikri Lok Sabha constituency () is one of the 80 Lok Sabha (parliamentary) constituencies in the Indian state of Uttar Pradesh. This constituency in Agra district came into existence in 2008 as a part of the implementation of delimitation of parliamentary constituencies based on the recommendations of the Delimitation Commission of India constituted in 2002.
Presently, Fatehpur Sikri Lok Sabha constituency comprises five Vidhan Sabha (legislative assembly) segments. These are:
Kheragarh, Fatehabad and Bah assembly segments were earlier in erstwhile Firozabad Lok Sabha constituency, while Fatehpur Sikri assembly segment was earlier in erstwhile Agra Lok Sabha constituency.