Farafangana is a district of Atsimo-Atsinanana in Madagascar. The district has an area of , and the estimated population in 2020 was 436,226.
The district is further divided into 30 communes:
There is an airport in Farafangana (Farafangana Airport). One of the main crops in the region is pepper.
Natives are mainly from ethnic groups Antefasy, Rabakara, Antesaka and Zafisoro.
Farafangana has a university.
The Manombo Reserve is located at 25 km to Farafangana.