Extermination or exterminate may refer to:
- Pest control, elimination of insects or vermin
- Extermination (crime), the killing of humans on a large scale
- Genocide, at least one of five "acts committed with intent to destroy, in whole or in part, a national, ethnical, racial or religious group"
- "Exterminate!", the battle cry of the Daleks in the British television show Doctor Who
- As a proper noun
- Extermination (comics), a Marvel Comics crossover event featuring the X-Men
- Extermination (video game), a 2001 PlayStation 2 game by Deep Space
- ExtermiNation, a 2015 album by heavy metal band Raven
- "Exterminate!" (song), a 1992 song by Snap!
See also