Examples of in vivo transdifferentiation by lineage-instructive approach

A list of examples of in vivo transdifferentiation through transfection:

• mouse hepatocytes → B cells (Pdx1)
• exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A)
• nonsensory cells → inner hair cells (Atoh1 and MathI)
• non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c)

Through excision:

• B-cell precursors → hematopoietic progenitors(-Pax5)
• In adult ovarian follicles, granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1)

See also

• Transdifferentiation
• Induced stem cells

References