Euphorbia nicaeensis is a species of flowering plant in the family Euphorbiaceae.
Euphorbia nicaeensis is a perennial, herbaceous plant or a shrub, reaching a height of about . It has erect, simple, ocher-orange stems, usually leafless and covered with leaf scars on most of its length. Leaves are glaucous gray, narrowly lanceolate, oblong or ovate, about long, arranged in apical rosettes and inflorescences. The flowering period extends from June to August.
This species can be found in southern and eastern Europe (Spain, Portugal, Italy, Croatia), in Turkey, in the Caucasus and in Algeria.