Eugene S. Clarke (born April 4, 1956) is a Republican former member of the Mississippi State Senate who resides in Hollandale in Washington County in western Mississippi.
Clarke was born in Greenville, Mississippi. He graduated from Mississippi State University at Starkville, at which he was a member of the Sigma Alpha Epsilon fraternity.
An accountant, Clarke is married to the former Paula Watkins. They have three children. He is a Methodist.