Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with WolffâÂÂParkinsonâÂÂWhite syndrome.
It is manufactured under the brand name Ethacizin (ÃÂÃÂðÃÂø÷øý) by Latvian pharmaceutical company Olainfarm.
For the treatment of heart infarction:
The amide formation between Phenothiazine-2-ethylcarbamate [37711-29-8] (1) and 3-Chloropropionyl chloride [625-36-5] (2) gives ethyl N-[10-(3-chloropropanoyl)phenothiazin-2-yl]carbamate [119407-03-3] [34749-22-9] (3). Displacement of the remaining ÃÂ-halogen by diethylamine (4) then completes the synthesis of ethacizine (5).