Est-Mono is a prefecture located in the Plateaux Region of Togo. The prefecture covers 2,599 km<sup>2</sup>, with a population in 2022 of 164,460. The prefecture seat is located in Elavagnon.
Cantons of Est-Mono include Elavagnon, Nyamassila, Kamina, Morétan-Igbérioko, Kpéssi, Gbadjahè, and Badin-Copé.