Essene is a submunicipality of Affligem in the Belgian province of Flemish Brabant. It was an independent municipality until the municipal reorganization of 1977. It is part of the Arrondissement of Halle-Vilvoorde and the .
Essene has several architectural heritage buildings, including several chapels, multiple farms, a brewery and a country house.
Essene was before the written as Esschene. After the French period Essene was incorporated into the of the Dyle department.