Espira-de-l'Agly (, literally Espira of the Agly; ) is a commune in the Pyrénées-Orientales department in southern France.
Espira-de-l'Agly is located in the canton of La Vallée de l'Agly and in the arrondissement of Perpignan. Espira-de-l'Agly is situated approximately 12 km outside Perpignan.