Esiẹ () is a town in Kwara State in Nigeria.
The town was founded by Prince Baragbon c. 1770. The dialect of Yoruba spoken in Esiẹ is predominantly Igbonna. The town has a king who is Oba Yakubu Babalola Egunjobi II.
It is home to the Esiẹ Museum which was the first museum to be established in Nigeria.